## Abstract Human lymphocytes and their subpopulations from the peripheral blood and pleural effusions of cancer patients were tested for cytotoxicity against fresh tumor cells isolated from carcinomatous pleural effusions of the same patients. Fresh tumor cells were relatively resistant to lysis b
Lysis of Fresh Human Tumor Cells by Autologous Peripheral Blood Lymphocytes and Tumor-infiltrating Lymphocytes Activated hy PSK
β Scribed by Kariya, Yoshitaka ;Okamoto, Norihiko ;Fujimoto, Takuya ;Inoue, Naoya ;Kihara, Takeshi ;Sugie, Katsuji ;Yagita, Masato ;Kanzaki, Hideharu ;Mori, Takahide ;Uchida, Atsushi
- Book ID
- 108579378
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1991
- Tongue
- English
- Weight
- 486 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0910-5050
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Peripheral blood lymphocytes (PBL) and tumor-infiltrating lymphocytes (TIL) were isolated from six cancer patients and cultured in the presence of 100 units/ml of recombinant interleukin 2 (IL2). Both IL2-stimulated PBL (IL2-PBL) and IL2-stimulated TIL (IL2-TIL) lysed fresh and short-term cultured a
Melanoma and renal-cell carcinoma (RCC) are generally consided to be relatively immunogenic tumor types in humans. In the case of melanoma, many major histocompatibility complex (MHC) class I-restricted tumor-specific cytotoxic T lymphocytes (Cn) have been isolated from either tumorinfiltrating lymp