## Abstract To identify tumor‐associated antigens as putative targets for developing immunotherapies against prostate cancer, we investigated the ability of T cells derived from the peripheral blood lymphocytes of prostate cancer patients to recognize autologous tumor cells. The technical challenge
Lymphocyte stimulation by autologous tumor cells in the presence of serum from the same patient or from healthy donors
✍ Scribed by F. Vánky; E. Klein; J. Stjernswärd; G. Trempe
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- French
- Weight
- 756 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
Lymphocyte blastogenesis induced by autologous tumor biopsy cells, by allogeneic lymphocytes and by PHA, was performed in the presence of autologous or allogeneic serum collected from normal blood donors. In 13 of the 15 cases lymphocyte stimulation by autologous tumor cells was inhibited in the presence of autologous serum. In contrast, autologous serum somewhat enhanced the blastogenic effect of PHA and allogeneic lymphocytes.
📜 SIMILAR VOLUMES
## Abstract IgG fractions from serum of patients with transitional‐cell carcinoma of the urinary bladder (TCC), patients with carcinoma of the prostate (CC) and healthy donors (HD) were tested for their capacity to induce antibody‐dependent lymphocyte‐mediated cytotoxicity (ADCC) to tumor cells in