Augmented human-tumor-cytolytic activity of peripheral blood lymphocytes and cells from a mixed lymphocyte/tumor culture activated by interleukin-12 plus interleukin-2, and the phenotypic characterization of the cells in patients with advanced carcinoma

Interleukin-12 delivered by biodegradabl

Interleukin-12 delivered by biodegradable microspheres promotes the antitumor activity of human peripheral blood lymphocytes in a human head and neck tumor xenograft/SCID mouse model

✍ M. Abraham Kuriakose; F-A Chen; Nejat K. Egilmez; Y.S. Jong; Edith Mathiowitz; M 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 138 KB 👁 1 views

Background. The role of cytokines in tumor regression is now well established. The major limitation for the clinical use of cytokines is the lack of a simple and effective protocol for the local and sustained delivery of cytokines to the tumor milieu. This study reports suppression of human head and