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Lymphocyte stimulation by acetylcholine receptor in polymyositis

✍ Scribed by B. M. Conti-Tronconi; M. Morgutti; M. G. Albizzati; F. Clementi

Publisher
Springer
Year
1978
Tongue
English
Weight
305 KB
Volume
217
Category
Article
ISSN
0340-5354

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✦ Synopsis

Lymphocytes of twenty-seven patients with polymyositis were incubated in vitro with cholinergic receptor rich membranes obtained from the electric organs of Torpedo Marmorata. Lymphocytes of polymyositic patients were slightly stimulated; positive responses were present mainly in patients affected from more than a year. Sensitization against the nicotinic cholinergic receptor may explain the occurrence of the myasthenic syndrome with polymyositis.

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