Lymphocyte phenotype and function in chronically transfused children with sickle cell disease
โ Scribed by Winfred Wang; Henry Herrod; Gerald Presbury; Judith Wilimas
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 571 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0361-8609
No coin nor oath required. For personal study only.
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Cerebrovascular accident (CVA) is a major complication of sickle cell disease during childhood. Long-term transfusion reduces the hemoglobin S level and generally prevents recurrent stroke, but it also results in progressive iron overload that requires regular chelation therapy. Erythrocytapheresis
We performed pulmonary function testing in 20 infants (11 male and 9 female; ages 3-30 months) with sickle cell disease to assess whether abnormal lung function develops early in life. Respiratory system compliance (C rs ) and resistance (R rs ) were measured by the passive occlusion technique, func