Immune regulation in chronically transfused allo-antibody responder and nonresponder patients with sickle cell disease and β-thalassemia major

Patterns of hepatic iron distribution in

Patterns of hepatic iron distribution in patients with chronically transfused thalassemia and sickle cell disease

✍ Nilesh R. Ghugre; Ignacio Gonzalez-Gomez; Ellen Butensky; Leila Noetzli; Roland 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 190 KB 👁 2 views

## Abstract Patients with sickle cell disease (SCD) appear to be at lower risk of endocrinopathies and cardiac dysfunction than those with thalassemia major (TM). Circulating redox active iron is lower in these patients, possibly due to increased systemic inflammation and circulating cytokines. Hep