Peripheral blood lymphocytes (PBL) and tumor-infiltrating lymphocytes (TIL) were isolated from six cancer patients and cultured in the presence of 100 units/ml of recombinant interleukin 2 (IL2). Both IL2-stimulated PBL (IL2-PBL) and IL2-stimulated TIL (IL2-TIL) lysed fresh and short-term cultured a
Lymphocyte-mediated lysis of autologous and allogeneic B-cell lines in man
β Scribed by Manuel Patarroyo; Eva Klein; George Klein
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 222 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0165-2478
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Blood lymphocyte subsets of various densities from 14 healthy donors and 25 patients with solid tumors were used in tests for cytotoxicity against allogeneic or autologous tumor cells. The allogeneic combinations comprised 36 tests on 28 tumors. In these the unmanipulated total lymphocyte population
## Abstract Freshly separated tumor cells from sarcomas and carcinomas were used in various roles in lymphocyteβtarget cell interaction assays. They were poorer allogeneic stimulators than lymphocytes. They were however good allotargets for the cytotoxicity generated in mixed lymphocyte cultures. T