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Luteolin modulates expression of drug-metabolizing enzymes through the AhR and Nrf2 pathways in hepatic cells

✍ Scribed by Zhang, Tianshun; Kimura, Yuki; Jiang, Songyan; Harada, Kiyonari; Yamashita, Yoko; Ashida, Hitoshi

Book ID: 124107628
Publisher: Elsevier Science
Year: 2014
Tongue: English
Weight: 919 KB
Volume: 557
Category: Article
ISSN: 0003-9861
DOI: 10.1016/j.abb.2014.05.023

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## Abstract Primary cultures of human hepatocytes and hepatoma cell line HepG2 are frequently used to evaluate the hepatic disposition of drugs and other xenobiotics. To check the variability of the expression of drug‐metabolizing enzymes in these in vitro models, expression of genes coding for sev