Lung surfactant proteins involved in innate immunity

✍ Scribed by Paul Eggleton; Kenneth BM Reid

• Book ID: 104359064
• Publisher: Elsevier Science
• Year: 1999
• Tongue: English
• Weight: 142 KB
• Volume: 11
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/s0952-7915(99)80006-5

✦ Synopsis

The two lung surfactant collectins, surfactant protein (SP)-A and SP-D, are involved in host defence against infectious and allergenic agents via enhancement of killing and clearance by macrophages and neutrophils. Recent gene-knockout, protein engineering and physiological studies have emphasised the roles that SP-A and SP-D play in acute inflammatory responses.