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LRRK2 variation and Parkinson's disease in African Americans

✍ Scribed by Owen A. Ross; Greggory J. Wilhoite; Justin A. Bacon; Alexandra Soto-Ortolaza; Jennifer Kachergus; Stephanie A. Cobb; Andreas Puschmann; Carles Vilariño-Güell; Matthew J. Farrer; Neill Graff-Radford; James F. Meschia; Zbigniew K. Wszolek

Book ID
102945521
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
639 KB
Volume
25
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

The global impact of LRRK2 mutations is yet to be realized with a lack of studies in specific ethnic groups, including those of Asian and African descent. Herein, we investigated the frequency of common LRRK2 variants by complete exon sequencing in a series of publicly available African American Parkinson's disease patients. Our study identified three novel synonymous exonic variants and 13 known coding variations; however, there did not appear to be any frequent (>5%) pathogenic mutations. Given the ethnic‐specific LRRK2 variation previously identified in PD further studies in under‐represented populations are warranted. © 2010 Movement Disorder Society.

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