LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles
✍ Scribed by Zhenyu Yue
- Book ID
- 111313215
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 216 KB
- Volume
- 276
- Category
- Article
- ISSN
- 1432-1327
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## Abstract Genealogical investigation of a large Norwegian family (F04) with autosomal dominant parkinsonism has identified 18 affected family members over four generations. Genetic studies have revealed a novel pathogenic __LRRK2__ mutation c.4309 A>C (p.Asn1437His) that co‐segregates with diseas
## Abstract Mutations in __LRRK2__ were first reported as causing Parkinson's disease (PD) in late 2004. Since then, approximately a dozen __LRRK2__ substitutions have been identified that are believed to be pathogenic mutations. The substitution of adenine for guanine at nucleotide 4541 (4541G>A)