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Low Ligand Loading, Highly Enantioselective Addition of Phenylacetylene to Aromatic Ketones Catalyzed by Schiff-Base Amino Alcohols

✍ Scribed by Chen, Chao; Hong, Liang; Xu, Zhao-Qing; Liu, Lei; Wang, Rui


Book ID
119979217
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
131 KB
Volume
8
Category
Article
ISSN
1523-7060

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πŸ“œ SIMILAR VOLUMES


Enantioselective Addition of Phenylacety
✍ Juan Ding; Zong-Xuan Shen; Xiao-Qing Luo; Wei-Yi Chen; Ya-Wen Zhang πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 69 KB πŸ‘ 2 views

## Abstract (__S__)‐(1‐Benzylpyrrolidin‐2‐yl)diphenylmethanol and cinchonine were evaluated as promotors in the asymmetric additions of phenylacetylene to ketones, in order to prepare chiral propargylic alcohols. Good yields (up to 89%) and moderate enantioselectivities (up to 77.9% __ee__) were ac

Enantioselective Addition of Phenylacety
✍ Shao-Hua Wang; Yong-Qiang Tu; Peng Chen πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 53 KB πŸ‘ 2 views

## Abstract The easily prepared and recoverable chiral __N__‐sulfonylated __Ξ²__‐amino alcohol **2** in combination with Ti(OPr‐__i__)~4~was found to be an effective chiral catalyst for the enantioselective addition of alkynylzinc to ketones, which gave the useful products, __i.e.__ chiral tertiary

Chiral ligands for asymmetric synthesis:
✍ Hongying Yun; Yangjie Wu; Yusheng Wu; Kuiling Ding; Ying Zhou πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 63 KB

A series of chiral ligands 2a-d were conveniently prepared from b-amino alcohols through a two-step sequence and applied to catalysis of enantioselective addition of diethylzinc to benzaldehyde. Among them ligand 2c was found to show the best asymmetric induction for the reaction and catalyze the ad