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Low levels of 3,3′-diindolylmethane activate estrogen receptor α and induce proliferation of breast cancer cells in the absence of estradiol

✍ Scribed by Maud Marques,Liette Laflamme,Ines Benassou,Coumba Cissokho…

Book ID
126371265
Publisher
BioMed Central
Year
2014
Tongue
English
Weight
714 KB
Volume
14
Category
Article
ISSN
1471-2407

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## Abstract Adipositas correlates with an enhanced risk of developing malignant diseases such as breast cancer, endometrial tumor or prostate carcinoma, but the molecular basis for this is not well understood. Potential mechanisms include increased bioavailability of adipocytokines (__e.g.__ leptin