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Low frequency of NRAS and KRAS2 gene mutations in childhood myelodysplastic syndromes

✍ Scribed by Biljana Jekic; Ivana Novakovic; Ljiljana Lukovic; Milos Kuzmanovic; Branka Popovic; Irena Pastar; Jelena Milasin; Gordana Bunjevacki; Vera Bunjevacki

Book ID
113512458
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
154 KB
Volume
154
Category
Article
ISSN
0165-4608

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## Abstract Mutational analysis of __KRAS__ codons 12 and 13 is standard for patients with metastatic colorectal cancer since mutations in these codons predict lack of response to anti‐EGFR therapies. However, even among patients whose tumors are wildtype for __KRAS__ codons 12 and 13, only a subse