Low frequency of germline E-cadherin mutations in familial and nonfamilial gastric cancer
β Scribed by Stone, J; Bevan, S; Cunningham, D; Hill, A; Rahman, N; Peto, J; Marossy, A; Houlston, R S
- Book ID
- 110002129
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 60 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0007-0920
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The International Gastric Cancer Linkage Consortium (IGCLC) predicted that up to 25% of families fulfilling the criteria for hereditary diffuse gastric cancer (HDGC) would harbor CDH1 germline mutations. This was based on observations from the low number of diffuse gastric cancer families described
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## Abstract Somatic mutations in the __Eβcadherin__ (__CDH1__) gene have frequently been reported in cases with diffuse gastric and lobular breast cancers. Recently, germline mutations have been identified in families with diffuse gastric cancers. In families with hereditary prostate cancer (HPC),
## Communicated by Henrik Dahl To extend earlier observations of germline E-cadherin mutations in kindreds with an inherited susceptibility to diffuse gastric cancer, we searched for germline E-cadherin mutations in five further families affected predominantly by diffuse gastric cancer and one fami