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Low frequency of allelic loss in the cyclin A gene in human hepatocellular carcinomas: a study based on PCR

✍ Scribed by Maria Stella Di Mitri; Emilio Pisi; Christian Bréchot; Patrizia Patarlini


Book ID
114796872
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
448 KB
Volume
13
Category
Article
ISSN
0106-9543

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## Abstract 6‐Mercaptopurine (6MP) is an essential anticancer drug used in the treatment of childhood acute lymphoblastic leukemia (ALL). Thiopurine methyltransferase (TPMT) polymorphisms are the major determinants of interindividual differences in the severe toxicity or efficacy of 6MP. Four varia