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Low-density lipoprotein receptor genotype-dependent response to cholesterol lowering by combined pravastatin and cholestyramine in familial hypercholesterolemia

✍ Scribed by Kouji Kajinami; Kunimasa Yagi; Toshinori Higashikata; Akihiro Inazu; Junji Koizumi; Hiroshi Mabuchi


Book ID
113979583
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
126 KB
Volume
82
Category
Article
ISSN
0002-9149

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Although the efficacy of fluvastatin (HMG-CoA reductase inhibitor) in the treatment of primary hypercholesterolemia is well documented, a wide interindividual variation treatment response has been observed. We have studied the possible role of the AvaII (exon 13), HincII (exon 12), and PvuII (intron