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Low conductance states of a single ion channel are not ‘closed’

✍ Scribed by Y. E. Korchev; C. L. Bashford; G. M. Alder; J. J. Kasianowicz; C. A. Pasternak

Book ID
104675791
Publisher
Springer
Year
1995
Tongue
English
Weight
636 KB
Volume
147
Category
Article
ISSN
0022-2631

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✦ Synopsis

We have used a polymer-exclusion method to estimate the sizes of the high- and low-conductance states of Staphylococcus aureus alpha-toxin channels across planar lipid bilayers. Despite a > 10-fold difference in conductance between high- and low-conductance states, the size differs by < 2-fold. We conclude that factors other than the dimensions have a strong influence on the conductance of alpha-toxin channels. We also show that the high conductance state is destabilized by the presence of high molecular weight polymers outside the channel, compatible with the removal of channel water as the high conductance state "shrinks" to the low conductance state.

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The Akaike information criterion (AIC) i
The Akaike information criterion (AIC) is not a sufficient condition to determine the number of ion channel states from single channel recordings
✍ Larry S. Liebovitch; Tibor I. Tóth 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 453 KB

The Akaike information criterion (AIC) and other criteria that trade off the goodness-of-fit against the number of parameters have been used to determine the number of ion channel states from single channel recordings. We show that, in general, such criteria are not valid. This is illustrated by an