Loss of β-catenin expression is associated with disease progression in malignant melanoma
✍ Scribed by J.E. Osborne
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 580 KB
- Volume
- 146
- Category
- Article
- ISSN
- 0007-0963
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Beyond depth of invasion, there are very few prognostic markers to predict outcome in melanoma. It has been shown recently that the β‐catenin oncogene is mutated or shows altered subcellular localization suggesting that activation of β‐catenin mediated signaling plays a role in oncogene
Cells of the melanocytic lineage have been shown to be capable of producing laminin and to lose this property during transformation. In the present study, we have evaluated im- munohistochemically whether these changes are paralleled by an altered expression of the a6@l laminin receptor. Results of
The P3.58 antigen is defined by monoclonal antibodies (MAbs) selected to discriminate between benign and malignant melanocytic cells. Its expression in malignant cells has been shown to correlate with an increased risk of metastasis. A survey of a wide range of tissues revealed that, on normal tissu