The ability of tumor cells to interact with the extracellular matrix (ECM) is functionally mediated by a variety of receptor molecules among which the integrins are a well-characterized family of mediators. In this study we have investigated irnmunohistochemically the in vivo expression of the a,/Pl
Integrin expression in cutaneous malignant melanoma: Association of the α3/β1 heterodimer with tumor progression
✍ Scribed by P. G. Natali; A. Bartolazzi; R. Cavaliere; A. Bigotti; M. R. Nicotra
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- French
- Weight
- 985 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Cells of the melanocytic lineage have been shown to be capable of producing laminin and to lose this property during transformation. In the present study, we have evaluated im- munohistochemically whether these changes are paralleled by an altered expression of the a6@l laminin receptor. Results of
The G 1 /S checkpoint of the cell cycle is regulated by p16, p53 and RB tumor suppressor genes. Loss of expression of the p16 INK4 tumor suppressor protein, the product of the CDKN2 gene, has been associated with a wide variety of human malignancies. Mutations, loss of heterozygosity and deletions o
The interindividual pharmacokinetic variability of the a 4 b 1 integrin antagonist -4582) was observed in beagles. The involvement of albumin genetic polymorphism in this variability was investigated. The albumin genotype was analyzed by sequencing the albumin gene from liver and blood samples. The