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Loss of Ubiquitin-Binding Associated With Paget's Disease of Bone p62 (SQSTM1) Mutations

✍ Scribed by James R Cavey; Stuart H Ralston; Lynne J Hocking; Paul W Sheppard; Barbara Ciani; Mark S Searle; Robert Layfield


Book ID
111485208
Publisher
American Society for Bone and Mineral Research
Year
2004
Tongue
English
Weight
351 KB
Volume
20
Category
Article
ISSN
0884-0431

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## Abstract Paget disease of bone (PDB) is a common disorder characterized by increased bone turnover at one of more sites throughout the skeleton. Genetic factors play an important role in the pathogenesis of PDB, and the most important predisposing gene is __SQSTM1__, which is mutated in about 10