Loss of T-cell receptor-CD3ζ and T-cell function in tumor-infiltrating lymphocytes but not in tumor-associated lymphocytes in ovarian carcinoma
✍ Scribed by Diane C. Lockhart; Allen K. Chan; Simona Mak; Hong-Gu Joo; Heather A. Daust; Amanda Carritte; Cara C. Douville; Peter S. Goedegebuure; Timothy J. Eberlein
- Book ID
- 117849504
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 173 KB
- Volume
- 129
- Category
- Article
- ISSN
- 0039-6060
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## Abstract It has been reported that in mice and in humans, tumor‐infiltrating lymphocytes (TIL) may exhibit a defect in CD3‐ζ‐chain expression. Therefore, the level of CD3‐ζ was analyzed in TIL derived from patients with renal‐cell carcinoma, and its correlation with TIL phenotype and function wa
Fresh suspensions of tumor-infiltrating lymphocytes (TIL) from 16 patients with squamous cell carcinoma of the head and neck (SCCHN) were examined for T-cell markers including CD4 (helper-inducer), CD8 (cytotoxic-suppressor), natural killer (NK) cell, and activation surface markers using monoclonal
Three-color immunofluorescence flow-cytometric analysis of freshly isolated tumor-infiltrating lymphocytes (TIL) from patients with primary renal cell carcinoma (RCC) revealed a unique, not previously described TIL subset with a CD3+ CD4+ CD8alpha++ CD8beta+ phenotype. This subset represented at lea