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Loss of Retinoblastoma Gene (RB1) Is Associated with Deletions at the 17p13.3 Chromosome and S-Phase Index in Human Breast Cancer

✍ Scribed by TIZIANA VENESIO; AMELIA BERNARDI; ANTONELLA SCORDAMAGLIA; PAOLO FERRERO; MONICA SALVEGO; ALBERTO P. M. CAPPA; DANIEL S. LISCIA


Book ID
119872761
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
212 KB
Volume
784
Category
Article
ISSN
0890-6564

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In primary human breast carcinomas mutat
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## Abstract A series of 121 human breast tumors was screened for point mutations in exons 5 through 8 of the p53 gene, by SSCP analysis. On the same tumor samples, the S‐phase index (SPI) was determined by the incorporation of BUdR in fresh tissue. p53 mutations were observed in 29% of the cases. T