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A Locus on Chromosome 17P13.3, Associated with a High S-Phase Index Is Distinct from the p53 Gene in Breast Cancer

✍ Scribed by DANIEL S. LISCIA; TIZIANA VENESIO; FRANCESCA DIELLA; AMELIA BERNARDI; ALBERTO P. M. CAPPA; ROBERT CALLAHAN; GIORGIO R. MERLO


Book ID
119868207
Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
299 KB
Volume
698
Category
Article
ISSN
0890-6564

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## Abstract A series of 121 human breast tumors was screened for point mutations in exons 5 through 8 of the p53 gene, by SSCP analysis. On the same tumor samples, the S‐phase index (SPI) was determined by the incorporation of BUdR in fresh tissue. p53 mutations were observed in 29% of the cases. T