✦ LIBER ✦

Loss of maternal allele in a child with myelodysplastic syndrome and monosomy 7

✍ Scribed by Aktas, Dilek; Yenicesu, Id?l; H?csonmez, Gonul; Tuncbilek, Ergul

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 72 KB
Volume: 62
Category: Article
ISSN: 0361-8609
DOI: 10.1002/(sici)1096-8652(199909)62:1<49::aid-ajh8>3.0.co;2-y

No coin nor oath required. For personal study only.

✦ Synopsis

Monosomy 7 or partial deletion of the long arm of chromosome 7 is frequently described in children with myelodysplastic syndrome and acute myeloblastic leukemia. Parental origin of chromosome 7 in children with sporadic monosomy 7 has been examined very rarely. To investigate if monosomy 7 shows parent-of-origin, we have studied a female child with monosomy 7 and de novo myelodysplastic syndrome by a series of polymorphic polymerase chain reaction markers. We found loss of maternal allele and discussed the results with the previous reports. Am.

📜 SIMILAR VOLUMES

Myelodysplastic syndrome in a child with

Myelodysplastic syndrome in a child with 15q24 deletion syndrome

✍ Yoko Narumi; Masaaki Shiohara; Keiko Wakui; Asahito Hama; Seiji Kojima; Kentaro 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 242 KB 👁 1 views

Erythroleukemia in a child associated wi

Erythroleukemia in a child associated with monosomy 7

✍ Toshiji Shitara; Shin-Ichiroh Yugami; Manabu Sotomatu; Yukio Oshima; Hiroko Ijim 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 266 KB 👁 1 views

Monosomy 7 myelodysplastic syndrome and

Monosomy 7 myelodysplastic syndrome and other second malignant neoplasms in children with neurofibromatosis type 1

✍ John M. Maris; Susan R. Wiersma; Nidal Mahgoub; Patricia Thompson; Russell J. Ge 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 126 KB 👁 2 views

## Background: Children with neurofibromatosis type 1 (nf1) are at increased risk of developing benign and malignant solid tumors as well as hematologic malignancies, including de novo juvenile chronic myelogenous leukemia, monosomy 7 syndrome, and acute myelogenous leukemia. the normal nf1 allele

Full mosaic monosomy 22 in a child with

Full mosaic monosomy 22 in a child with DiGeorge syndrome facial appearance

✍ Pinto-Escalante, Doris; Ceballos-Quintal, Jose M.; Castillo-Zapata, Ileana; Cant 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 24 KB 👁 2 views

We describe an abnormal premature male infant with mosaic monosomy of chromosome 22. He had a unique facial appearance, similar to those with DiGeorge syndrome, and hypertonicity, limitation of extension at major joints, and flexion contractures of all fingers. This rare chromosomal aberration has b

Neutrophilic infiltration of the myocard

Neutrophilic infiltration of the myocardium in a patient with myelodysplastic syndrome

✍ Shimizu, Kazuyuki 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 55 KB 👁 2 views

A 64-year-old woman presented with cardiomegaly, Sweet's syndrome, and refractory anemia (RA), and died of sudden cardiac arrest. The autopsy revealed a perivascular and myocardial infiltration by neutrophils, which could be responsible for the cardiomegaly and probably had caused disturbances in th

Novel 7-DHCR mutation in a child with Sm

Novel 7-DHCR mutation in a child with Smith-Lemli-Opitz syndrome

✍ Patrono, C.; Rizzo, C.; Tessa, A.; Giannotti, A.; Borrelli, P.; Carrozzo, R.; Pi 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 12 KB 👁 2 views

Smith-Lemli-Opitz syndrome (SLOS) is an autosomal recessive disorder characterized by minor facial anomalies, mental retardation, and multiple congenital abnormalities. Biochemically, the disorder is caused by deficient activity of 7-dehydrocholesterol reductase, which catalyzes the reduction of the