Myelodysplastic syndrome in a child with 15q24 deletion syndrome
β Scribed by Yoko Narumi; Masaaki Shiohara; Keiko Wakui; Asahito Hama; Seiji Kojima; Kentaro Yoshikawa; Yoshiro Amano; Tomoki Kosho; Yoshimitsu Fukushima
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 242 KB
- Volume
- 158A
- Category
- Article
- ISSN
- 1552-4825
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A balanced Robertsonian translocation 45,XY,t(15q15q) was detected in a patient with mental retardation, microcephaly, and hypertonia. Deletion of the 15qllq13 region was unlikely based on fluorescence in situ hybridization studies that revealed hybridization of appropriate DNA probes to both arms o
We describe a male infant with unusual facial appearance, relative pancytopenia, bilateral simian creases, and an accessory nipple. Cytogenetic analysis showed deletion of the long arm of chromosome 11 [46,XY,del(11)(pter-->q23.2:)]. Bone-marrow study showed a myelodysplastic change of hemopoietic c