Loss of imprinting of insulin-like growth factor II is associated with increased risk of proximal colon cancer
β Scribed by Jyh-Ming Liou; Ming-Shiang Wu; Jaw-Town Lin; Hsiu-Po Wang; Shih-Pei Huang; Han-Mo Chiu; Yi-Chia Lee; Yen-Bo Lin; Chia-Tung Shun; Jin-Tung Liang
- Book ID
- 116429289
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 233 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0959-8049
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## Abstract The most common known molecular defect in Wilms tumor (WT) of the kidney, the most frequent solid tumor of childhood, is loss of imprinting (LOI) of the insulinβlike growth factorβII gene (__IGF2__), which involves activation of the normally silent maternal allele of the gene and hyperm
## Abstract Loss of imprinting (LOI), the biallelic expression of an imprinting gene, of insulinβlike growth factor 2 (__IGF2__) has been reported to be associated with colorectal carcinogenesis because of its high prevalence in normal colorectal mucosa as well as cancerous tissue in patients with