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Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability

✍ Scribed by Cui, Hengmi; Horon, Isabelle L.; Ohlsson, Rolf; Hamilton, Stanley R.; Feinberg, Andrew P.

Book ID
109748548
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
161 KB
Volume
4
Category
Article
ISSN
1078-8956

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Microsatellite instability in colorectal
Microsatellite instability in colorectal-cancer patients with suspected genetic predisposition
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Hereditary non-polyposis colorectal cancer (HNPCC) is a dominantly inherited syndrome linked to DNA-mismatch-repair (MMR) gene defects, which also account for microsatellite instability (MSI) in tumour tissues. Diagnosis is based mainly on family history, according to widely accepted criteria (Amste