Genomic imprinting is a parental origin-specific chromosomal modification that causes differential expression of maternal and paternal alleles of a gene. Accumulating evidence suggests that deregulation of imprinted genes, including loss of imprinting (LOI), plays a role in oncogenesis. In the prese
โฆ LIBER โฆ
Loss of imprinting and overexpression of IGF2 gene in gastric adenocarcinoma
โ Scribed by Ming-Shiang Wu; Hsiu-Po Wang; Chun-Che Lin; Jin-Chuan Sheu; Chia-Tung Shun; Wei-Jei Lee; Jaw-Town Lin
- Book ID
- 117468585
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 161 KB
- Volume
- 120
- Category
- Article
- ISSN
- 0304-3835
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Loss of imprinting (LOI) of the igf 2 and h19 genes has been found not only in embryonal tumors but also in common adult cancers. To determine any possible role of genomic imprinting in the development of renal-cell carcinomas (RCCs), we examined the imprinting status of igf 2 and h19 in a series of
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