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Loss of high-affinity agonist receptor binding in Alzheimer's disease

โœ Scribed by Jacques De Keyser


Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
111 KB
Volume
31
Category
Article
ISSN
0364-5134

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Loss of presenilin function causes Alzhe
โœ Qian Chen; Akira Nakajima; Se Hoon Choi; Xiaoli Xiong; Ya-Ping Tang ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 448 KB

## Abstract Accumulating evidence has indicated that gainโ€ofโ€function in ฮฒโ€amyloid production may be not the necessary mechanism for mutant presenilinโ€1 (PS1) or PS2 to cause familial Alzheimer's disease (AD). In the present article, we show that conditional knockout of PS1 from the adult stage in