Forty-four breast carcinomas were studied for loss of heterozygosity (LOH) at 25 microsatellite markers distributed almost evenly along chromosome arm 22q. LOH at at least one marker were observed in 66% tumors, while 6 regions of consistent LOH were identified. The size of each region ranged betwee
Loss of heterozygosity on the long arm of human chromosome 7 in sporadic renal cell carcinomas
β Scribed by Shridhar, Viji; Sun, Qi C; Miller, Orlando J; Kalemkerian, Gregory P; Petros, John; Smith, David I
- Book ID
- 110061023
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 353 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0950-9232
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## Abstract Loss of heterozygosity (LOH) on the long arm of chromosome 7 was examined using 5 polymorphic marker probes on 98 gastric carcinomas to elucidate a novel locus for development and progression of the tumors. Twentyβsix (32%) of 82 informative cases showed LOH on 7q on at least one locus
We examined 88 nonpapillary renal cell carcinomas for allelic loss at chromosome arm 14q and correlated the results to size, grade, and stage of these tumors. Fourteen highly polymorphic microsatellite markers on the long arm of chromosome 14 were used for deletion mapping. Loss of heterozygosity (L