## Abstract This study reports on the evaluation of the Wilms tumor suppressor gene __WT1__ in 14 endometrial carcinomas. Despite the fact that several endometrial carcinomas were shown to express __WT1__, we were unable to demonstrate mutations in the __MT1__ zinc finger region, suggesting that __
Loss of heterozygosity of the Wilms' tumor suppressor gene (WT1) in in situ and invasive breast carcinoma
โ Scribed by Aurelie Fabre; Amanda H McCann; Donal O'Shea; Dennise Broderick; George Keating; Brendan Tobin; Thomas Gorey; Peter A Dervan
- Book ID
- 117253652
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 542 KB
- Volume
- 30
- Category
- Article
- ISSN
- 1532-8392
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The expression of the Wilms tumor suppressor gene WT1 is largely restricted to elements of the developing urogenital system. In the fetal kidney, WT1 transcripts are present at low levels in the condensing mesenchyme and at much higher levels in differentiating glomerular epithelium and are not dete
The genetic events underlying the development of prostate cancer are poorly defined. c-Myc is often activated in tumors that have progressed to metastatic status, so events that promote this process may be important. Bin1 is a nucleocytoplasmic adaptor protein with features of a tumor suppressor tha