Loss of heterozygosity of the adenomatous polyposis coli gene is a common event in Barrett' s cancers
โ Scribed by TA Wright; J Field; AN Kingsnorth
- Book ID
- 118880218
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 137 KB
- Volume
- 108
- Category
- Article
- ISSN
- 0016-5085
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## BACKGROUND. The majority of colorectal carcinomas, if not all, arise from a benign adenoma. The DNA of the carcinomatous cells frequently has mutations in several genes. However, it is not exactly clear when during the neoplastic process each mutation develops. An adenoma with an area of in sit
Loss of heterozygosity (LOH) from the short arm of chromosome 8 (8p) is common t o many human carcinomas, including those of the colon and prostate. It localizes to two discrete regions, 8p21 and 8p22. This suggests the presence of at least two tumor suppressor genes (TSGs) on this chromosome arm. H