Rhabdoid tumors of the kidney are highly malignant neoplasms that occur primarily within the first 3 years of life. Although they are regarded as distinct from Wilms' tumors, their pathogenesis remains unclear. Whereas most cytogenetic studies of these tumors have revealed normal karyotypes, a few r
β¦ LIBER β¦
Loss of heterozygosity at chromosome 11p15 in Wilms tumors: identification of two independent regions
β Scribed by Karnik, Pratima; Chen, Ping; Paris, Mark; Yeger, Herman; Williams, Bryan RG
- Book ID
- 110061447
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 348 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0950-9232
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## Incidence rates of Wilms' tumor (WT) markedly differ in East Asian and Caucasian children. In the present study, we examined WT1 deletions/mutations and loss of heterozygosity (LOH) on 11p and 11q in a large number of WTs and compared our findings with those from 4 series of Caucasian WTs. Inci