𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Loss of heterozygosity at 9p21 loci and mutations of the MTS1 and MTS2 genes in human lung cancers

✍ Scribed by Tatsunori Shimizu; Takao Sekiya

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
861 KB
Volume
63
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

To elucidate the involvement of abnormalities of the MTS1/p16 and MTS2/p15 genes located at chromosomal region 9p21 in human lung cancers, we analyzed DNA from 30 primary lung cancers and detected loss of heterozygosity at the 9p21‐p23 region in 15 tumors. Single‐strand‐conformation‐polymorphism analysis of polymerase‐chain‐reaction products from the MTS1 and MTS2 genes and determination of the nucleotide sequences revealed the presence of a mutated MTS1 gene in 2 of 15 tumors with a loss of corresponding loci. No mutations of the MTS2 gene were found. These results suggested that mutations of the MTS1 gene are associated with at least some human lung cancers. © 1995 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Loss of heterozygosity on chromosome 9 a
Loss of heterozygosity on chromosome 9 and p16 (MTS1, CDKN2) gene mutations in esophageal cancers
✍ Françoise Muzeau; Jean François Fléjou; Gilles Thomas; Richard Hamelin 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 131 KB 👁 1 views

Loss of heterozygosity on chromosome 9 has been reported in a variety of human cancers. The cyclin-dependent kinase inhibitor p16 gene, mapped on chromosome 9p21, is presumed to be the tumor-suppressor gene localized in this chromosome. The aim of our study was to determine, in 26 Barrett's adenocar

Molecular analysis of the cyclin-depende
Molecular analysis of the cyclin-dependent kinase inhibitor genes p15INK4b/MTS21, p16INK4/MTS1, p18 and pl9 in human cancer cell lines
✍ Akihiko Gemma; Seiichi Takenoshita; Koichi Hagiwara; Aikou Okamoto; Elisa A. Spi 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 660 KB

Cyclin-dependent kinillre-4 inhibitor genes (INK4) regulate the cell cycle and are candidate tumor-suppressor genes. To determine if alterations in the coding regions of the p18 and p l 9 genes, which are novel members of the INK4 family and if they correlate with the development of human cancer, 10

Frequent loss of heterozygosity in early
Frequent loss of heterozygosity in early non-small cell lung cancers at chromosome 9p21 proximal to the CDKN2a gene
✍ Leeanne J. Mead; Matthew T. Gillespie; Jaclyn Y. Hung; Usha S. Rane; Kathleen C. 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 105 KB 👁 2 views

Deletions involving the chromosome 9p21 region have been reported as frequent events in non-small cell lung cancer (NSCLC). To investigate potential tumor-suppressor gene (TSG) loci within the 9p21 region, which also harbors the candidate TSG locus CDKN2a, we studied 32 cases of primary NSCLC for lo

Hypermethylation of the tumor suppressor
Hypermethylation of the tumor suppressor gene RASSFIA and frequent concomitant loss of heterozygosity at 3p21 in cervical cancers
✍ Mei Y. Yu; Joanna H.M. Tong; Paul K.S. Chan; Tin L. Lee; Michael W.Y. Chan; Anth 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 162 KB 👁 1 views

## Abstract Loss of heterozygosity (LOH) at chromosome 3p21 is frequent in cervical cancers. The candidate tumor suppressor gene, __RASSF1A__ located at 3p21.3, is found to be inactivated in several major human cancers, implicating its significance in carcinogenesis. We aimed to investigate the sta

Frequent loss of heterozygosity at telom
Frequent loss of heterozygosity at telomeric loci on 22q in sporadic colorectal cancers
✍ Ikuo Yana; Hiroki Kurahashi; Shoji Nakamori; Masao Kameyama; Tsutomu Nakamura; M 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 552 KB

To date, several tumor-suppressor genes responsible for the tumorigenesis of colorectal cancer have been identified. However, studies of loss of heterozygosity (LOH) have suggested several chromosomal regions which may contain additional tumor-suppressor genes for colorectal cancer. To determine the

Growth arrest and suppression of tumorig
Growth arrest and suppression of tumorigenicity of bladder carcinoma cell lines induced by the P16/CDKN2 (p16INK4A, MTS1) gene and other loci on human chromosome 9
✍ Qiang Wu; Laura Possati; Marco Montesi; Francesca Gualandi; Paola Rimessi; Crist 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 889 KB

## Wild -type P16ICDKNZ MTSI) cDNA, directed by the cytomegalovirus (CMV) immediate early promoter, was transfected into RT4 and RTI I 2 bladder-carcinoma cell lines bearing a mutated endogenous P16ICDKNZ gene and lacking endogenous P 16lCDKN2 respectively. In both cases, only transfected clones w