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Loss of heterozygosity at 15q21.3 correlates with occurrence of metastases in head and neck cancer

✍ Scribed by Poetsch, Micaela; Kleist, Britta


Book ID
109888489
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
279 KB
Volume
19
Category
Article
ISSN
0893-3952

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Background. Loss of heterozygosity (LOH) correlates with inactivated tumor suppressor genes. The aim of this study was to see if LOH on chromosomes 2q, 3p, 5q, 9p, and 17p correlated with survival in early squamous cell carcinoma of the head and neck (SCCHN). Methods. A case control study was perfo

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## Abstract Loss of heterozygosity (LOH) in chromosomal regions that harbor tumor suppressor genes from tumor tissue may lead to decreased survival time in cancer patients with squamous cell carcinoma of the head and neck (HNSCC). We studied 8 regions frequently lost in HNSCC in 150 patients having