We have used B6C3F1 mice heterozygous at Aprt (adenine phosphoribosyltransferase) as a model to study in vivo loss of heterozygosity (LOH) in normal splenic T-lymphocytes. APRT-deficient T-cells were selected in medium containing 50 g/ml 2,6-diaminopurine (DAP), an adenine analog that is toxic only
Loss of heterozygosity and point mutation at Aprt locus in T cells and fibroblasts of Pms2−/− mice
✍ Scribed by Shao, Changshun; Yin, Moying; Deng, Li; Stambrook, Peter J; Doetschman, Thomas; Tischfield, Jay A
- Book ID
- 110066557
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 162 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0950-9232
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Hodgkin's lymphoma (HL) is a lymphoid malignancy characterized by the presence of rare neoplastic cells, Hodgkin and Reed‐Sternberg (HRS) cells, scattered among a predominant population of inflammatory cells. On the basis of previously reported cytogenetic analyses, the __ATM__ (ataxia‐
## Abstract DAL‐1/4.1B (__EPB41L3__)is a member of the protein 4.1 superfamily, which encompasses structural proteins that play important roles in membrane processes via interactions with actin, spectrin, and the cytoplasmic domains of integral membrane proteins. __DAL‐1/4.1B__ localizes within chr
## Abstract To elucidate the involvement of abnormalities of the MTS1/__p16__ and __MTS2/p15__ genes located at chromosomal region 9p21 in human lung cancers, we analyzed DNA from 30 primary lung cancers and detected loss of heterozygosity at the 9p21‐p23 region in 15 tumors. Single‐strand‐conforma