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Loss-of-Function Mutations in PPARγ Associated with Human Colon Cancer

✍ Scribed by Pasha Sarraf; Elisabetta Mueller; Wendy M Smith; Harold M Wright; Jennifer B Kum; Lauri A Aaltonen; Albert de la Chapelle; Bruce M Spiegelman; Charis Eng

Book ID: 117736717
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 212 KB
Volume: 3
Category: Article
ISSN: 1097-2765
DOI: 10.1016/s1097-2765(01)80012-5

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## Abstract Heat‐induced cell death appears to be a cell‐specific event. Chronic heat stress was lethal to human colon cancer cells (Caco‐2, HT29, and HCT116), but not to normal diploid fibroblasts and other cancer cells (BJ‐T, WI38, HeLa, ovarian 2008, WI38VA). Acute heat stress (45–51°C, 30 min)