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Loss of function germline mutations in RAD51D in women with ovarian carcinoma

โœ Scribed by Anneka Wickramanyake; Greta Bernier; Christopher Pennil; Silvia Casadei; Kathy J. Agnew; Sunday M. Stray; Jessica Mandell; Rochelle L. Garcia; Tom Walsh; Mary-Claire King; Elizabeth M. Swisher


Book ID
118506863
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
351 KB
Volume
127
Category
Article
ISSN
0090-8258

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Analysis of RAD51C germline mutations in
โœ Ella R. Thompson; Samantha E. Boyle; Julie Johnson; Georgina L. Ryland; Sarah Sa ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 180 KB

There is strong evidence that overtly inactivating mutations in RAD51C predispose to hereditary breast and ovarian cancer but the prevalence of such mutations, and whether they are associated with a particular clinical phenotype, remains unclear. Resolving these questions has important implications