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Loss of constitutional heterozygosity in colon carcinoma from patients with familial polyposis coli

โœ Scribed by Okamoto, Mieko; Sasaki, Masayuki; Sugio, Kenji; Sato, Chieko; Iwama, Takeo; Ikeuchi, Tatsuro; Tonomura, Akira; Sasazuki, Takehiko; Miyaki, Michiko

Book ID
109751945
Publisher
Nature Publishing Group
Year
1988
Tongue
English
Weight
528 KB
Volume
331
Category
Article
ISSN
0028-0836

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## BACKGROUND. The majority of colorectal carcinomas, if not all, arise from a benign adenoma. The DNA of the carcinomatous cells frequently has mutations in several genes. However, it is not exactly clear when during the neoplastic process each mutation develops. An adenoma with an area of in sit