The expression of the adhesion molecule CD44 was examined in 14 primary sinonasal melanomas (SMs), aggressive neoplasms with short survival times, as CD44 overexpression has been linked to poor survival in human cancers. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded section
Loss in expression of the retinoblastoma gene product in human gliomas is associated with advanced disease
โ Scribed by Wolfgang Hamel; Manfred Westphal; H. Michael Shepard
- Publisher
- Springer US
- Year
- 1993
- Tongue
- English
- Weight
- 801 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0167-594X
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The retinoblastoma gene (RB) encodes a tumor suppressor that is inactivated in a number of different types of cancer. We searched for gross alterations of this gene in tumors of the central nervous system by using Southern blot hybridization. A common alteration was found in several tumors and was m
Paraffin sections (n = 168, 27 benign, 16 low malignant potential [LMP] and 125 malignant tumours) from epithelial ovarian tumours were evaluated immunohistochemically for expression of retinoblastoma gene product (pRB) and p53 protein, and the relationship among pRB, p53 and cyclin-dependent kinase