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Loperamide modifies the tissue disposition kinetics of ivermectin in rats

โœ Scribed by Adrian L. Lifschitz; Guillermo L. Virkel; Juan M. Sallovitz; Alejandra Pis; Fernanda A. Imperiale; Carlos E. Lanusse

Book ID
111769024
Publisher
Pharmaceutical Press
Year
2004
Tongue
English
Weight
296 KB
Volume
56
Category
Article
ISSN
2042-7158

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โœ Patricia A. Cleveland; Clarence T. Ueda ๐Ÿ“‚ Article ๐Ÿ“… 1985 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 529 KB

The effects of ibuprofen on maternal phenytoin pharmacokinetics and fetal phenytoin acquisition were investigated in 19-day gestation Sprague-Dawley rats. A 5 mg kg-' bolus injection of I4C-phenytoin was given with and without (control) pretreatment with 12.5 mg kg-' of ibuprofen. Maternal plasma an