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Effect of imatinib mesilate on the disposition kinetics of ciclosporin in rats

โœ Scribed by Takashi Kajita; Yasuhiko Higashi; Masanobu Imamura; Chieko Maida; Youichi Fujii; Ikuyoshi Yamamoto; Etsuko Miyamoto

Book ID
111770563
Publisher
Pharmaceutical Press
Year
2006
Tongue
English
Weight
101 KB
Volume
58
Category
Article
ISSN
2042-7158

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โœ Patricia A. Cleveland; Clarence T. Ueda ๐Ÿ“‚ Article ๐Ÿ“… 1985 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 529 KB

The effects of ibuprofen on maternal phenytoin pharmacokinetics and fetal phenytoin acquisition were investigated in 19-day gestation Sprague-Dawley rats. A 5 mg kg-' bolus injection of I4C-phenytoin was given with and without (control) pretreatment with 12.5 mg kg-' of ibuprofen. Maternal plasma an