Looking into the grooves of DNA

Measuring the geometry of DNA grooves

✍ E. Stofer; R. Lavery 📂 Article 📅 1994 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 761 KB

We present a new method for measuring the widths and depths of the grooves formed within DNA helices. This method overcomes the limitations of simply measuring interstrand phosphate-phosphate distances and has the advantage of yielding continuous values for groove geometry along a DNA fragment. In t

Crystallographic insights into DNA minor

Crystallographic insights into DNA minor groove recognition by drugs

✍ Stephen Neidle 📂 Article 📅 1997 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 385 KB 👁 2 views

This review surveys the crystal structures between minor groove drugs and oligonucleotides, of which over thirty have now been determined. The various factors that are involved in the observed A/T sequence selectivity of these drugs are examined in structural terms. The roles of, in particular, hydr

Into the Looking Glass

✍ John Ringo 📂 Fiction 📅 2005 🏛 Baen Books, Distributed by Simon & Schuster 🌐 en-us ⚖ 175 KB 👁 2 views

Investigating a mammoth explosion that destroyed the University of Central Florida, physicist William Weaver and Navy SEAL Robert Miller discover demonic alien visitors intent on annihilating all life on Earth.

Into the Looking Glass

✍ Ringo, John 📂 Fiction 📅 2005 🏛 Baen Books, Distributed by Simon & Schuster 🌐 English ⚖ 175 KB 👁 2 views

Investigating a mammoth explosion that destroyed the University of Central Florida, physicist William Weaver and Navy SEAL Robert Miller discover demonic alien visitors intent on annihilating all life on Earth.

Into the Looking Glass

✍ John Ringo 📂 Fiction 📅 2005 🏛 Baen Books, Distributed by Simon & Schuster 🌐 English ⚖ 178 KB 👁 3 views

WORST TWO OUT OF THREE When a 60 kiloton nuclear explosion destroys the University of Central Florida, terrorism is the first suspect. But terrorists don't generally leave doorways to another world in their wake. Or, rather, a generator of doorways to multiple other worlds. With time of the essenc

Looking back into the future

✍ Uwe Bornscheuer 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 130 KB