𝔖 Bobbio Scriptorium
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Longitudinal study of bone age in acute lymphoblastic leukaemia

✍ Scribed by Tamminga, Rienk Y. J. ;Zweens, Marjan ;Kamps, Willem ;Drayer, Nick

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
414 KB
Volume
21
Category
Article
ISSN
0098-1532

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✦ Synopsis

Abstract

Bone age was assessed in children with acute lymphoblastic leukaemia (ALL) using the Tanner‐Whitehouse II method. X‐rays of the left hand (wrist) were made at diagnosis and annually until 5 years after diagnosis. A total of 164 X‐rays from 40 patients was available. During treatment bone age development as well as height growth was retarded in relation to calendar age. A catch‐up of bone age and height was observed in the 2 years after cessation of treatment. No significant differences could be found between patients with and without cranial irradiation as central nervous system treatment. Therefore cranial irradiation alone is not responsible for the growth retardation of children with ALL; the causative role of cytostatic drug therapy and/or corticosteroids has to be investigated. Β© 1993 Wiley‐Liss, Inc.

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