Long-term therapy with adefovir dipivoxil in hepatitis B e antigen-negative patients developing resistance to lamivudine
β Scribed by S. MANOLAKOPOULOS; S. BETHANIS; S. KOUTSOUNAS; J. GOULIS; J. VLACHOGIANNAKOS; E. CHRISTIAS; A. SAVERIADIS; C. PAVLIDIS; C. TRIANTOS; A. CHRISTIDOU; G. PAPATHEODORIDIS; D. KARAMANOLIS; D. TZOURMAKLIOTIS
- Book ID
- 108605196
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 158 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0269-2813
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Progression of hepatitis B in patients with lamivudine-resistant strains is slowed down by adefovir dipivoxil (ADV). Whether the time point of ADV administration (genotypic vs. phenotypic resistance) influences the outcome of therapy is unknown. We compared the outcome of ADV therapy in hepatitis B
Wait-listed (n Ο 226) or post-liver transplantation (n Ο 241) chronic hepatitis B (CHB) patients with lamivudine-resistant hepatitis B virus (HBV) were treated with adefovir dipivoxil for a median of 39 and 99 weeks, respectively. Among wait-listed patients, serum HBV DNA levels became undetectable
## Abstract The aims of this study were to assess the longβterm efficacy of lamivudine (LAM) plus adefovir dipivoxil (ADV) combination therapy in patients with chronic hepatitis B resistant to LAM, to identify predictive factors of complete viral response (HBVβDNA <2.6βlogβcopies/ml at 12 months of
## Abstract Factors influencing the therapeutic efficacy of adefovir dipivoxil added to continuing lamivudine have not been elucidated in lamivudineβresistant patients with type B chronic hepatitis. The viral mutations influencing the efficacy of treatment with adefovir dipivoxil were investigated