We determined the clinical outcome of hepatitis e antigen (HBeAg)-negative chronic hepatitis B patients treated with long-term nucleos(t)ide analog therapy starting with lamivudine. We evaluated 201 such patients treated for 3.8 ؎ 1.4 years and 2 historical similar cohorts: 1 treated with interferon
Long-Term Therapy of Chronic Hepatitis B With Lamivudine
✍ Scribed by Daryl T Lau; M Farooq Khokhar; Edward Doo; Marc G Ghany; David Herion; Yoon Park; David E Kleiner; Peter Schmid; Lynn D Condreay; Josée Gauthier; Mary C Kuhns; T Jake Liang; Jay H Hoofnagle
- Book ID
- 111721157
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 259 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0270-9139
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## Abstract The long‐term efficacy of lamivudine therapy in patients with hepatitis B virus (HBV) infection is still not clear. In this study, 20 non‐cirrhotic Japanese patients infected with HBV received lamivudine therapy for more than 1 year and were followed for a median period of 8.5 years (ra
One year of lamivudine treatment results in increased hepatitis B e antigen (HBeAg) seroconversion and serum hepatitis B virus (HBV) DNA negativity in children with chronic hepatitis B and high serum alanine aminotransferase concentrations. Two hundred seventy-six children who participated in a 1-ye