Long-term results with interferon therapy in chronic type B hepatitis: a prospective randomized trial
β Scribed by Giuseppe Mazzella; Giorgio Saracco; Davide Festi; Floriano Rosina; Sabrina Marchetto; Francesca Jaboli; Raffaello Sostegni; Alessandro Pezzoli; Francesco Azzaroli; Claudio Cancellieri; Marco Montagnani; Enrico Roda; Mario Rizzetto
- Book ID
- 119396486
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 78 KB
- Volume
- 94
- Category
- Article
- ISSN
- 0002-9270
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Thirty-six children with chronic hepatitis B were entered into a randomized controlled trial of recombinant human interferon-a. All patients had hepatitis B virus DNA and increased levels of aminotransferases in serum for at least 1 yr. Twelve children received 10 MU of interferon-a 2b/m2 body surfa
Interferon-a therapy leads to HBeAg seroconversion in only one third of patients with chronic hepatitis B. In an attempt to increase the seroconversion rate, we investigated the combination of interferon-a and zidovudine in a subset of patients with presumably low response rates for interferon-a mon