Interferon alfa therapy for chronic hepatitis B in children: A multinational randomized controlled trial
✍ Scribed by Etienne Marc Sokal*; Hari S. Conjeevaram‡; Eve A. Roberts§; Fernando Alvarez∥; Elana M. Bern¶; Philippe Goyens#; Philip Rosenthal**; Alain Lachaux‡‡; Mark Shelton§§; Jacques Sarles∥∥; Jay Hoofnagle¶¶
- Book ID
- 118520271
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 106 KB
- Volume
- 114
- Category
- Article
- ISSN
- 0016-5085
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Thirty-six children with chronic hepatitis B were entered into a randomized controlled trial of recombinant human interferon-a. All patients had hepatitis B virus DNA and increased levels of aminotransferases in serum for at least 1 yr. Twelve children received 10 MU of interferon-a 2b/m2 body surfa
## Steroid priming does not potentiate the effect of IFN-a. The comparative efficacy of prednisolone followed by (HEPATOLOGY 1996;23:700-707.) interferon alfa (IFN-a) versus IFN-a alone in enhancing the rate of antibody to hepatitis B e antigen (anti-HBe) seroconversion has not been evaluated in a