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Long-term remission of blastic natural killer-cell lymphoma after autologous peripheral blood stem-cell transplantation

✍ Scribed by Masaki Yamaguchi; Mio Maekawa; Yoshihisa Nakamura; Mikio Ueda

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
120 KB
Volume
80
Category
Article
ISSN
0361-8609

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✦ Synopsis

Abstract

We report here a case of blastic natural killer (NK)‐cell lymphoma treated successfully with autologous peripheral blood stem‐cell transplantation (APBSCT). A 57‐year‐old man had skin tumors and was diagnosed as having blastic NK‐cell lymphoma by tumor biopsy. Skin, lymph nodes, left tonsil, and bone marrow were involved at presentation. Chemotherapy led to complete remission (CR). To sustain CR, the patient underwent high‐dose chemotherapy in combination with 12 Gy of total‐body irradiation (TBI) followed by autologous peripheral blood stem‐cell rescue. He showed rapid recovery of hematopoiesis and could tolerate regimen‐related toxicity after APBSCT. He has maintained long‐term remission for 20 months after APBSCT. From this case, we concluded that APBSCT with preconditioning by TBI‐containing regimens might be a cure‐attaining treatment for disseminated blastic NK‐cell lymphoma and should be considered as a choice of treatment in cases where no suitable donors for allogeneic transplantation are available. Am. J. Hematol. 80:124–127, 2005. © 2005 Wiley‐Liss, Inc.

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